public string WeightField {get; set;}

string colorBrewerSchemesName = "ArcGIS Colors";
StyleProjectItem style = Project.Current.GetItems<StyleProjectItem>().First(s => s.Name == colorBrewerSchemesName);
string colorRampName = "Heat Map 4 - Semitransparent";
IList<ColorRampStyleItem> colorRampList = await QueuedTask.Run(() =>
{
  return style.SearchColorRamps(colorRampName);
});
ColorRampStyleItem colorRamp = colorRampList[0];

await QueuedTask.Run(() =>
{
  //defining a heatmap renderer that uses values from Population field as the weights
  HeatMapRendererDefinition heatMapDef = new HeatMapRendererDefinition()
  {
    Radius = 20,
    WeightField = "Population",
    ColorRamp = colorRamp.ColorRamp,
    RendereringQuality = 8,
    UpperLabel = "High Density",
    LowerLabel = "Low Density"
  };

  FeatureLayer flyr = MapView.Active.Map.Layers[0] as FeatureLayer;
  CIMHeatMapRenderer heatMapRndr = flyr.CreateRenderer(heatMapDef) as CIMHeatMapRenderer;
  flyr.SetRenderer(heatMapRndr);
});