var layout = LayoutView.Active.Layout;
var mf = layout.GetElementsAsFlattenedList().OfType<MapFrame>()
.First(mf => mf.Name == mapFrame);
var autoCamera = mf.GetAutoCamera();
autoCamera.Source = AutoCameraSource.Fixed;
autoCamera.AutoCameraType = AutoCameraType.Center;
var camera = mf.GetMapView(LayoutView.Active).Camera;
var center = mf.GetViewCenter();
//var extent = EnvelopeBuilderEx.CreateEnvelope(
// 400748.62, 800296.4, 1310669.05, 1424520.74, mf.Map.SpatialReference);
//autoCamera.Extent = extent;
var camera2 = new CIMViewCamera()
{
Heading = 0,
Pitch = -90,
Roll = 0,
Scale = 21169571,
X = 855708,
Y = 1112409,
Z = double.NaN
};
autoCamera.Camera = camera2;
var states = mf.Map.GetLayersAsFlattenedList().First(l => l.Name == "State_Polygons");
autoCamera.IntersectLayerPath = states.URI;
if (mf.ValidateAutoCamera(autoCamera) &&
!mf.IsMapSeriesMapFrame())
mf.SetAutoCamera(autoCamera);